Effect of vaginal probiotics containing Lactobacillus casei rhamnosus (Lcr regenerans) on vaginal dysbiotic microbiota and pregnancy outcome, prospective, randomized study

Abstract The intermediate bacterial microbiota is a heterogeneous group that varies in the severity of the Grill Dish dysbiosis, from minor deficiency to total absence of vaginal Lactobacillus spp.We treated women with this vaginal dysbiosis in the first trimester of pregnancy using a vaginally applied lactobacilli preparation to restore the normal

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Evidence for long-term association of virion-delivered HBV core protein with cccDNA independently of viral protein production

Background & Aims: HBV persists in the nucleus of infected hepatocytes as a covalently closed circular DNA (cccDNA) episome that Harnesses Pickup constitutes the template for viral RNA and protein synthesis.Both HBx and HBc (core) viral proteins associate with cccDNA but, while HBx is required for viral transcription, the role of HBc is still u

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